Table 3.
Bile acid levels in human brain tissue.
| Bile Acid | Control (n = 10) | AD (n = 10) | p-Value |
|---|---|---|---|
| CA | 0.16 ± 0.04 | 0.24 ± 0.1 | 0.39 |
| CDCA | 0.33 ± 0.11 | 0.65 ± 0.32 | 0.41 |
| DCA | 0.37 ± 0.11 | 1.84 ± 1.39 | 0.47 |
| GCA | 0.13 ± 0.03 | 0.10 ± 0.02 | 0.25 |
| GCDCA | 0.19 ± 0.08 | 0.14 ± 0.05 | 0.49 |
| GDCA | 0.06 ± 0.02 | 0.10 ± 0.04 | 0.46 |
| GLCA | <LOD | <LOD | - |
| GLCAS | <LLOQ | <LLOQ | - |
| GUDCA | <LLOQ | <LLOQ | - |
| HDCA | <LLOQ | <LLOQ | - |
| LCA | 0.06 ± 0.02 | 0.05 ± 0.01 | 0.44 |
| α-MCA | <LOD | <LOD | - |
| β-MCA | <LOD | <LOD | - |
| Ω-MCA | <LLOQ | <LLOQ | - |
| TCA | 0.06 ± 0.02 | 0.01 ± 0.006 | 0.01 |
| TCDCA | 0.11 ± 0.03 | 0.04 ± 0.01 | 0.07 |
| TDCA | <LLOQ | <LLOQ | - |
| TLCA | <LOD | <LOD | - |
| TLCAS | <LOD | <LOD | - |
| TMCA (α + β) | <LOD | <LOD | - |
| TUDCA | <LOD | <LOD | - |
| UDCA | 0.06 ± 0.01 | 0.16 ± 0.09 | 0.31 |
Concentrations presented are nmol/g (mean ± SEM). <LOD = Below the limit of detection. <LLOQ = Below the lower limit of quantification. Significant p-values are in bold.