Table 4.
Bile acid levels in mouse brain.
| Bile Acid | 6 Months | 12 Months | ||||
|---|---|---|---|---|---|---|
| Control (n = 5) | APP/PS1 (n = 5) | p-value | Control (n = 5) | APP/PS1 (n = 5) | p-Value | |
| CA | 0.09 ± 0.01 | 0.10 ± 0.02 | 0.47 | 0.28 ± 0.08 | 0.08 ± 0.02 | 0.02 |
| CDCA | <LOD | <LOD | - | <LOD | <LOD | - |
| DCA | 0.07 ± 0.01 | 0.09 ± 0.02 | 0.35 | 0.05 ± 0.003 | 0.04 ± 0.01 | 0.17 |
| GCA | <LOD | <LOD | - | <LOD | <LOD | - |
| GCDCA | <LLOQ | <LLOQ | - | <LLOQ | <LLOQ | - |
| GDCA | <LOD | <LOD | - | <LOD | <LOD | - |
| GLCA | <LOD | <LOD | - | <LOD | <LOD | - |
| GLCAS | <LOD | <LOD | - | <LOD | <LOD | - |
| GUDCA | <LOD | <LOD | - | <LOD | <LOD | - |
| HDCA | <LOD | <LOD | - | <LOD | <LOD | - |
| LCA | 0.01 ± 0.01 | 0.04 ± 0.01 | 0.05 | 0.04 ± 0.01 | 0.05 ± 0.02 | 0.47 |
| α-MCA | <LOD | <LOD | - | <LOD | <LOD | - |
| β-MCA | 0.08 ± 0.02 | 0.07 ± 0.02 | 0.37 | 0.24 ± 0.06 | 0.08 ± 0.04 | 0.02 |
| Ω-MCA | 0.05 ± 0.01 | 0.03 ± 0.01 | 0.22 | 0.08 ± 0.02 | 0.03 ± 0.01 | 0.05 |
| TCA | 0.10 ± 0.03 | 0.06 ± 0.03 | 0.11 | 0.16 ± 0.07 | 0.04 ± 0.02 | 0.04 |
| TCDCA | <LOD | <LOD | - | <LOD | <LOD | - |
| TDCA | <LOD | <LOD | - | <LOD | <LOD | - |
| TLCA | <LOD | <LOD | - | <LOD | <LOD | - |
| TLCAS | <LOD | <LOD | - | <LOD | <LOD | - |
| TMCA (α + β) | 0.14 ± 0.02 | 0.08 ± 0.03 | 0.05 | 0.25 ± 0.07 | 0.04 ± 0.01 | 0.002 |
| TUDCA | 0.02 ± 0.01 | 0.02 ± 0.002 | 0.33 | 0.03 ± 0.01 | 0.01 ± 0.001 | 0.02 |
| UDCA | <LOD | <LOD | - | <LOD | <LOD | - |
Concentrations presented are nmol/g (mean ± SEM). <LOD = Below the limit of detection. <LLOQ = Below the lower limit of quantification. Significant p-values are in bold.