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Oncogenic signals regulate the mitochondrial dynamics machinery to drive changes in mitochondrial morphology. Oncogenic MAPK, PI3K/Akt, and Ras-like guanine nucleotide exchange factor (RalGEF) signals promote mitochondrial fragmentation downstream of oncogenic Ras. Myc activity and canonical Wnt signaling, on the other hand, promote mitochondrial fusion, while non-canonical Wnt signaling and hypoxia induce fragmentation.
