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. 2017 Jun 8;9(6):187. doi: 10.3390/toxins9060187

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Four of the species examined here have sequences that are strikingly similar to the α subunit of the nociceptive toxin (MitTx) from Micrurus tener venom, which even the closely related M. fulvius lacks. Nonetheless, the South American Micrurus toxins have five substitutions (indicated by triangles), four of which are strongly non-synonymous. Signal peptides 24 residues long were essentially invariant (MSSGG LLLLL GLLTL CAELT PVSS). Only M. l. lemniscatus toxin DN110178 had a G/R substitution in position 5.