Table 6.

Power-model analysis of dose proportionality for AAFP doses (100, 125, 200, 400, 500, and 625 mg) for pooled data from Study 101 and Study 102

PK parameters	Statistics	Power model: P = a × Doseb
		a	b
AUC0–∞	Parameter estimates	0.7810	0.9864
	95% CI-lower limit	0.3891	0.8640
	95% CI-upper limit	1.5677	1.1089
	P value	0.4845	<0.0001
AUC0–t	Parameter estimates	0.6163	1.0146
	95% CI-lower limit	0.2994	0.8877
	95% CI-upper limit	1.2688	1.1415
	P value	0.1874	<0.0001
C max	Parameter estimates	0.3304	0.8648
	95% CI-lower limit	0.1574	0.7345
	95% CI-upper limit	0.6937	0.9951
	P value	0.0037	<0.0001

AAFP abiraterone acetate fine particle, AUC _0–∞ area under the plasma concentration–time curve from time zero to infinity, AUC _0–t area under the plasma concentration–time curve from time zero to the time of the last quantifiable concentration, CI confidence interval, C _max maximum plasma concentration, PK pharmacokinetic