| Antagonism of M3 muscarinic receptors (antaM3) has been related to the development of hyperglycemia. |
| Recent exposure to antidepressants with antaM3 activity was associated with an increased risk for type 2 diabetes mellitus in the adult population, but exposure to antidepressants without antaM3 was not. |
| This association was dose dependent and more pronounced in patients who were in the younger age group (<45 years old), were female and had no co-morbidity. |
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