Figure 1.

Illustrations of human and canine BRCA1 and BRCA2 proteins. All known canine coding variants in BRCA1 (Panel A) and BRCA2 (Panel B) proteins are noted on the diagram. Known human variants reported in Breast Cancer Information Core (BIC) within 2 amino acids of the conserved position of a canine variant were noted as well; the conserved human residues and locations were determined through a protein alignment. Hot pink text indicates conserved canine and human amino acid residues with variants; see Panel C for amino acid alignment. ^#variants found only in CMT‐affected dogs;^{^}claimed to be associated with CMT; ^&predicted to be pathogenic in respective papers; and ^%initially suspected pathogenic but is now considered neutral, and ^@named as reported in Hsu et al. due to lack of information presented, which limited locating variant within NM_001006653 and Broad CanFam3.1/canFam3.

Human protein accession numbers: BRCA1: NP_009231, BRCA2: NP_000050; Canine protein accession numbers: BRCA1: NP_001013434, BRCA2: NP_001006654