Table 5.
Frequencies of genotypes at DC-SIGN rs735240 in NPC patients and healthy controls.
| Genotype | Cases | Controls | Unadjusted OR (95%CI) | P | Adjusted OR∗(95%CI) |
Adjusted P | Adjusted OR▲ (95%CI) |
Adjusted P | P HWE |
|---|---|---|---|---|---|---|---|---|---|
| rs735240 | 0.937 | ||||||||
| AA | 24 | 28 | 1.000 | 1.000 | 1.000 | ||||
| AG | 161 | 193 | 0.973 (0.543–1.745) | 0.927 | 1.044 (0.574–1.901) | 0.887 | 2.976 (1.123–7.888) | 0.028 | |
| GG | 292 | 339 | 1.005 (0.570–1.772) | 0.986 | 1.077 (0.601–1.927) | 0.804 | 3.314 (1.274–8.622) | 0.014 | |
| AG + GG | 453 | 532 | 0.993 (0.568–1.738) | 0.982 | 1.065 (0.600–1.891) | 0.830 | 3.191 (1.237–8.230) | 0.016 |
∗Calculated using multiple logistic regression after controlling for age, sex, and smoking history; ▲calculated using multiple logistic regression after controlling for age, sex, smoking history, and EBV-VCA-IgA status. CI: confidence interval; DC-SIGN: dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin; HWE: Hardy-Weinberg equilibrium; NPC: nasopharyngeal carcinoma; OR: odds ratio.