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. 2017 May 3;242(2):178–192. doi: 10.1002/path.4891

Figure 3.

PATH-4891-FIG-0003-c

BMP and Notch signalling are partially segregated in normal colonic crypts but co‐localize in some human CRCs. (A) Relative mRNA expression levels of BMP and Notch pathway ligands, receptors and target genes in the bottom versus the top of hemisected individual normal human colonic crypts (n = 30, three patients). (B) Serial sections of normal human colonic tissue stained with Ki67‐specific and HES1‐specific antibodies and ID1 mRNA probe (magnification: ×200). (C) Serial sections of human colon tumours stained with HES1‐specific antibody and ID1 mRNA probe showing presence and co‐localization (Cancer 1) or differential expression (Cancer 2) of Notch and BMP pathway target genes, respectively, in CRCs. These are representative images from analysis of 105 paraffin‐embedded tumours. SEM, standard error of the mean.