Figure 4.

Location of hot1-4 Suppressor Mutations in AtHsp101.

Class 1 loss-of-function suppressors are labeled in smaller gray font and indicated with closed circles. Restoration-of-function Class 2 suppressors are indicated in larger black font with open circles. The strongest Class 2 suppressors, as discussed in the text, are underlined (see also Supplemental Figure 1 online).