SELP dynamic hydrogel designs inspired by the nature of the environmental
stimulus. (a) SELPs respond to temperature, a physical stimulus, exemplified by
S2E8C and S2E8F. (b) SELPs
respond to pH, a chemical stimulus, exemplified by S2E8E.
(c) SELPs respond to phosphorylation, a biological stimulus, exemplified by
S2E8R. (d) Gaussian fits to the distribution of
structures characterized by root mean square deviation (RMSD) from extended
linear conformation at a range of temperatures for the X=V
sequence. (e) Mean RMSD values for the X=V sequence indicating
a transition from extended to folded conformations. (f) Gaussian fits to the
distribution of structures characterized by root mean square deviation (RMSD)
from extended linear conformation at a range of temperatures for the
X=K sequence. (g) Mean RMSD values for the
X=K sequence suggesting a suppressed transition.