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. Author manuscript; available in PMC: 2017 Jun 28.
Published in final edited form as: Cancer Res. 2010 Jan 1;70(1):57–67. doi: 10.1158/0008-5472.CAN-09-2472

Figure 3.

Figure 3

Acute depletion of hepatic IGF-I does not affect subcutaneous tumor growth in obese mice. Mice were maintained on regular chow or high-calorie diet for 8 to 10 wk. A single injection of tamoxifen (0.4 mg) was administered to both control and iLID mice 4 d before or after the subcutaneous inoculation of 5 × 105 MC-38 cells per mouse. Tumors were removed and weighted. Columns, mean weights (g; n > 15 mice per group); bars, SEM. *, P < 0.05 as compared to mice fed regular chow within the same group; **, P < 0.05 as compared to control group fed the same diet.