FIG. 5.

Longitudinal CT analysis of a 10.74 Gy WTLI NHP, at baseline and followed every 30 days through the end of study. Transverse images taken at the apex, mid and base of lungs are shown in Fig. 4. Panel A: Total lung volume (TLV) is outlined in light blue, pleural effusion (PE) in green, pericardial effusion (PCE) in red and pneumonitis/fibrosis (PF) in pink. Quantitative results of PF:TLV and PE:TLV are given for each study day and represented as percentages of TLV. Pleural effusion and pneumonitis/fibrosis were observed at day 30–120 and day 120–180 postirradiation, respectively. Pericardial effusion was observed on day 90 and day 120, (21.68 ml and 9.77 ml, respectively). Furosemide (red bar) was administered on day 56–62 postirradiation for the presence of abdominal swelling per veterinary prescription. Dexamethasone (blue bars) was administered at day 54–62 and day 121–146 postirradiation due to NSRR above 80 bpm in accordance with study protocol. Panel B: Longitudinal CT analysis of a NHP receiving 10.74 Gy WTLI at baseline and followed every 30 days through to early euthanasia on day 101 in accordance with study criteria. Total lung volume (TLV) is outlined in light blue, pleural effusion (PE) in green, pericardial effusion (PCE) in red and pneumonitis/fibrosis (PF) in pink. Quantitative results of PF:TLV and PE:TLV are given for each study day and represented as percentages of TLV. Pleural effusion and pneumonitis/fibrosis were observed at day 30–90 and at day 60–101 postirradiation, respectively. Pericardial effusion (13.08 ml) was observed on day 60. Dexamethasone (blue bars) administered at day 79–91 and day 93–101 postirradiation due to NSRR above 80 bpm according to study protocol.