Table 2.
Comparison of sWGS, Hi-C and deep WGS costs
| Costs (£)a | Rearrangement detection? | Copy number detection? | |||
|---|---|---|---|---|---|
| Library prep | Sequencing | Total per sample | |||
| sWGS | 71 | 30–82 | 101–153 | N | Y |
| Hi-C | 165 | 211 | 376 | Y | Y |
| Deep WGS | 44 | 1270 | 1314 | Y | Y |
aBased on in-house protocols and costs using the Illumina HiSeq 4000. sWGS prepared using Illumina Nextera DNA library kit and 20–50 million 50 bp single end reads. Hi-C sequencing costs based on six samples per lane, 150 bp paired end. Deep WGS prepared using Illumina TruSeq DNA PCR-Free and one lane of 150 bp paired end sequencing (approx. 30x coverage)