Table 1. Selected upregulated genes in CDS and eMCs expressing CIC-DUX4.
| Gene name | FC in tumor* | FC in eMC* | Gene product |
|---|---|---|---|
| Muc5ac | 4663.1 | ** | mucin 5AC |
| Crh | 3686.0 | ** | corticotropin releasing hormone |
| Zic1 | 2680.2 | 23.5 | zinc finger protein |
| Etv4 | 2239.8 | ** | ets variant gene |
| Etv1 | 2023.7 | 39.1 | ets variant gene |
| Col24a1 | 987.2 | ** | collagen, type XXIV, alpha 1 |
| Fgfbp3 | 940.2 | ** | fibroblast growth factor binding protein |
| Etv5 | 611.2 | 42.0 | ets variant gene |
| Col9a1 | 441.7 | 50.7 | collagen, type IX, alpha 1 |
| Col13a1 | 230.5 | ** | collagen, type XIII, alpha 1 |
| Col9a3 | 192.6 | 45.8 | collagen, type IX, alpha 3 |
| Fli1 | 142.5 | 15.8 | Friend leukemia integration 1 |
| Col8a2 | 140.2 | 40.3 | collagen, type VIII, alpha 2 |
| Fmod | 132.2 | 51.0 | fibromodulin |
| Irf4 | 113.5 | ** | interferon regulatory factor 4 |
| Cdkn2a | 81.5 | ** | cyclin-dependent kinase inhibitor 2A |
| Kit | 62.4 | 29.7 | kit oncogene |
| Bcl2 | 41.4 | 19.6 | B-cell leukemia/lymphoma 2 |
| Col25a1 | 21.4 | 16.2 | collagen, type XXV, alpha 1 |
| Ccnd2 | 11.4 | ** | cyclin D2 |
| Cdkn1c | 7.3 | *** | cyclin-dependent kinase inhibitor 1C |
| Ccnd1 | 5.1 | *** | cyclin D1 |
| Gpc3 | 5.1 | *** | glypican 3 |
| Ets1 | 4.0 | ** | ets transcription factor |
| Col8a1 | 3.6 | ** | collagen, type VIII, alpha 1 |
| Vcan | 3.1 | ** | versican |
*
fold change (FC) of gene expression versus eMCs with an empty vector
**
fold change >1.5 with p > 0.05
***
not upregulated
Genes upregulated in human CDS are underlined.