Figure 2.

Syndromic features of patients 1 and 3. (A) Image of patient 1 at one month old demonstrating macrocephaly, facial hyperaemia and mildly asymmetric overgrowth. (B) Cutaneous syndactyly between the second and third toe on the right foot of P1. (C) Image of P1 at age 27 months demonstrating macrocephaly, obesity and overgrowth. (D and E) Head and facial features of P3 at 27 months showing macrocephaly, hypertrichosis, coarse facial appearance. (F) Deep palmar creases and excess skin in P3.