Table II.
Determination of cytotoxicity concentration (CC50) and anti-hepatitis B virus activity (inhibition of HBsAg secretion via IC50) and the corresponding TI of the plant extracts.
| Plant name | Extraction solvent | Yield (%) | CC50 (µg/ml) | IC50 (µg/ml) | TI |
|---|---|---|---|---|---|
| Abutilon figarianum | EtOH | 8.71 | 366.67 | 106.46 | 3.44 |
| Hex | 1.10 | 1700.00 | NA | ND | |
| DCM | 0.64 | 1375.02 | 99.76 | 13.78 | |
| EtAc | 0.48 | 332.30 | NA | ND | |
| MeOH | 8.02 | 284.70 | NA | ND | |
| Aqua | 2.21 | NC | NA | ND | |
| Acacia oerfota | EtOH | 11.13 | 1375.00 | 101.46 | 13.55 |
| Hex | 2.64 | 1150.10 | NA | ND | |
| DCM | 0.19 | 960.00 | NA | ND | |
| EtAc | 0.79 | NC | NA | ND | |
| MeOH | 5.54 | 383.30 | 118.90 | 3.22 | |
| Aqua | 9.60 | 422.20 | 106.84 | 3.95 | |
| Capparis decidua | EtOH | 10.31 | 366.67 | 76.85 | 4.77 |
| Hex | 0.27 | 383.30 | NA | ND | |
| DCM | 0.51 | 400.00 | NA | ND | |
| EtAc | 0.18 | 833.10 | NA | ND | |
| MeOH | 3.86 | 1667.67 | NA | ND | |
| Aqua | 6.86 | 520.00 | 66.82 | 7.78 | |
| Coccinia grandis | EtOH | 8.71 | 219.44 | 31.57 | 6.95 |
| Hex | 1.33 | 800.00 | NA | ND | |
| DCM | 0.86 | 480.01 | 57.14 | 8.40 | |
| EtAc | 0.32 | NC | NA | ND | |
| MeOH | 7.28 | 800 | NA | ND | |
| Aqua | 5.61 | 557.14 | 87.21 | 6.38 | |
| Corallocarpus epigeus | EtOH | 7.35 | 1275.00 | 71.90 | 17.73 |
| Hex | 0.86 | 150.00 | NA | ND | |
| DCM | 0.50 | 112.90 | NA | ND | |
| EtAc | 0.31 | 153.37 | NA | ND | |
| MeOH | 0.72 | 2500.00 | NA | ND | |
| Aqua | 2.61 | 1094.00 | 70.91 | 15.42 | |
| Fumaria parviflora | EtOH | 9.35 | NC | 79.84 | ND |
| Hex | 0.88 | 425.00 | 35.44 | 11.99 | |
| DCM | 0.62 | 188.10 | NA | ND | |
| EtAc | 1.02 | 221.98 | NA | ND | |
| MeOH | 8.10 | 1950.00 | 79.19 | 24.62 | |
| Aqua | 2.61 | 766.67 | NA | ND | |
| Guiera senegalensis | EtOH | 9.76 | 1566.00 | 73.21 | 21.39 |
| Hex | 0.52 | 3330.00 | NA | ND | |
| DCM | 0.74 | 200.00 | 10.65 | 18.77 | |
| EtAc | 0.62 | 450.10 | NA | ND | |
| MeOH | 7.32 | 1000.06 | NA | ND | |
| Aqua | 2.08 | 370.69 | 76.67 | 4.83 | |
| Indigofera caerulea | EtOH | 8.61 | 1455.00 | 84.62 | 17.19 |
| Hex | 0.62 | 230.43 | NA | ND | |
| DCM | 0.66 | 208.00 | NA | ND | |
| EtAc | 0.42 | 642.80 | NA | ND | |
| MeOH | 2.47 | 1566 | 73.21 | 21.39 | |
| Aqua | 4.06 | 1250.00 | 125.10 | 9.99 | |
| Pulicaria crispa | EtOH | 12.17 | 686.71 | 23.10 | 29.72 |
| Hex | 1.24 | 160.10 | NA | ND | |
| Pulicaria crispa | DCM | 1.64 | 79.31 | NA | ND |
| EtAc | 0.48 | 603.00 | 14.45 | 41.04 | |
| MeOH | 7.80 | 258.33 | 141.72 | 1.82 | |
| Aqua | 4.41 | 733.30 | NA | ND |
CC50, 50% cytotoxicity concentration; IC50, half maximal inhibitory concentration; Hex, hexane; DCM, dichloromethane; EtOAc, ethyl acetate; MeOH, methanol; Aqua, water; NC, non-cytotoxic; NA, not active; TI, therapeutic index; ND, not determined.