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. 2017 Jun 27;9:46. doi: 10.1186/s13195-017-0274-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Hippocampal atrophy in Tg4510 mice is unaffected by treatment with TOMA. Hippocampal volume was estimated from tissue sections through the entire hippocampus using the method of Cavalieri. Volume is expressed in cubic millimeters. Tg4510 mice treated with TOMA or IgG are significantly reduced relative to nontransgenic mice (*p < 0.05). Tet mice are not different from any of the other groups. Data presented as mean ± SEM. Ntg nontransgenic mice, TOMA tau oligomer monoclonal antibody, Tet Tet-only mice