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. 2017 May 22;14(1):147–154. doi: 10.3892/etm.2017.4490

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Copyright: © Zhu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Alterations in expression levels of molecules associated with the NLRP3 inflammasome pathway and its downstream product, IL-1β, after blocking the T-lymphocyte K_v1.3 channel in the hypertensive subjects. T-lymphocytes were incubated in the culture medium with or without 4-AP for 48 h. (A) Reverse transcription-quantitative polymerase chain reaction and (B) western blot analysis showed the relative mRNA and protein expression levels, respectively, of NLRP3, caspase-1 and IL-1β. These expression levels were significantly lower in the 4-AP group compared with the blank control group. (C) ELISA results indicated that the IL-1β content in the culture medium supernatant was significantly lower in the 4-AP group. *P<0.05 vs. Control. 4-AP, 4-aminopyridine; K_v1.3, voltage-gated K⁺ channel 1.3; IL-1β, interleukin-1β; NLRP3, NLR family pyrin domain containing 3.