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Effects of metformin on kidney function in rats with type 2 diabetes nephropathy. (A) Serum creatinine (SCr), (B) urine creatinine (UCr), (C) creatinine clearance (CCr), (D) blood urea nitrogen (BUN) and (E) 24-h urinary albumin excretion rate (UAER) were assessed. Data are presented as the mean ± standard error of the mean. *P<0.05, **P<0.01 and ***P<0.001, vs. the normal group; #P<0.05 and ##P<0.01, vs. the model group.
