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. 2017 Jun 9;13(6):932. doi: 10.15252/msb.20167490

Figure 4. hu.MAP consists of predominately core human complexes and covers a large fraction of disease genes.

Figure 4

  1. Complex map coverage of Human Protein Atlas RNA tissue specificity classifications showing majority of complexes are ubiquitously expressed and likely core cellular machinery.
  2. Fraction of complexes with significantly enriched annotation terms (g:Profiler hypergeometric test with FDR (Benjamini–Hochberg) correction on each complex and further corrected at an FDR of 5% given a set of shuffled complexes; see Materials and Methods) from various ontologies.
  3. Protein coverage of high‐level Disease Ontology terms and cilia‐related annotations for complex map as well as three published maps (Wan et al, BioPlex, Boldt et al) and three published interaction network (Hein et al, Gupta et al and Boldt et al).