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. Author manuscript; available in PMC: 2018 Jun 1.

Published in final edited form as: Pharm Res. 2017 Mar 28;34(6):1224–1232. doi: 10.1007/s11095-017-2139-x

Fig. 1 — Identification of the RD-MTD of DHA-dFdC following five i.v. injections (on days 0, 3, 7, 10, and 13 (▲)) in healthy DBA/2 mice (n = 8). (A) Percent of body weight change (* p < 0.05, 70 mg/kg vs. Untreated, one-way ANOVA followed by a Bonferroni post hoc test). (B) Survival curves. Log-rank (Mantel-Cox) test did not reveal any significant difference among groups. (C) Percent of body weight change at 40 mg/kg of DHA-dFdC. Student’s t-test did not reveal any difference. In A and C, data shown are mean ± S.D.

Fig. 1 — Identification of the RD-MTD of DHA-dFdC following five i.v. injections (on days 0, 3, 7, 10, and 13 (▲)) in healthy DBA/2 mice (n = 8). (A) Percent of body weight change (* p < 0.05, 70 mg/kg vs. Untreated, one-way ANOVA followed by a Bonferroni post hoc test). (B) Survival curves. Log-rank (Mantel-Cox) test did not reveal any significant difference among groups. (C) Percent of body weight change at 40 mg/kg of DHA-dFdC. Student’s t-test did not reveal any difference. In A and C, data shown are mean ± S.D.