Table 3.
Age-, sex-, and diabetes-adjusted adiposity and metabolic factors by GIR tertiles
| Variable | GIR | |||
|---|---|---|---|---|
|
| ||||
| Tertile 1 | Tertile 2 | Tertile 3 | p-value | |
| PAT/SAT† | 0.27 (0.22–0.33) | 0.27 (0.23–0.32) | 0.23 (0.19–0.28) | 0.264 |
| PAT (mL)† | 43.6 (36.6–52.0) | 35.8 (30.8–41.8) | 28.5 (23.7–34.1) | 0.003 |
| SAT (mL)† | 161.4 (131.5–198.1) | 133.7 (111.8–160.0) | 124.9 (100.8–154.8) | 0.127 |
| VAT (mL)† | 59.1 (49.1–71.1) | 43.3 (36.8–51.0) | 33.0 (27.3–40.0) | <0.001 |
| BMI (kg/m2)* | 28.5 (26.8–30.3) | 25.7 (24.2–27.2) | 24.9 (23.1–26.6) | 0.011 |
| Waist circumference (cm)* | 94.6 (90.2–98.9) | 86.2 (82.5–89.8) | 82.3 (78.0–86.5) | 0.001 |
| Waist to hip* | 0.87 (0.85–0.90) | 0.84 (0.82–0.86) | 0.80 (0.77–0.82) | <0.001 |
| RQ* | 0.01 (−0.01–0.03) | 0.07 (0.05–0.09) | 0.13 (0.11–0.16) | <0.001 |
| Fasting FFA* | 505.6 (432.8–578.5) | 551.2 (489.3–613.1) | 541.1 (469.5–612.7) | 0.540 |
| FFA suppression (%)* | 7.1 (−9.1–23.2) | 50.2 (36.4–63.9) | 69.4 (53.5–85.3) | <0.001 |
| Total adiponectin (μg/mL)† | 7.8 (6.1–10.1) | 9.5 (7.7–11.7) | 11.3 (8.7–14.7) | 0.081 |
| HMW adiponectin (μg/mL)† | 3.2 (2.2–4.5) | 4.2 (3.1–5.7) | 5.1 (3.6–7.3) | 0.097 |
Abbreviations: GIR, glucose infusion rate; PAT, pericardial adipose tissue; SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue; BMI, body mass index; RQ, respiratory quotient; FFA, free fatty acids; HMW, high molecular weight
*
Data presented as least squares adjusted means (95% CI), p-value from linear regression with GIR tertiles as an ordinal predictor, adjusted for age, sex, and diabetes
†
Data presented as least squares adjusted geometric mean (95% CI), p-value from linear regression with log transformed dependent variable and GIR tertiles as an ordinal predictor, adjusted for age, sex, and diabetes