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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Cancer Lett. 2017 Apr 26;400:37–46. doi: 10.1016/j.canlet.2017.04.029

Figure 3. Oxidative metabolism is enhanced in low pH culture conditions.

Figure 3

(A) LC-MS/MS-based metabolomics analysis of TCA cycle metabolites in control (7.4) and low pH (7.0) culture conditions. (B) 3H-glutamine uptake of S2-013 and Capan-1 in control and low pH conditions. (C) Intracellular ATP levels of S2-013 and Capan-1 in control and low pH conditions. (D) Sensitivity of S2-013 and Capan-1 cells to oligomycin in control and low pH. Data in bar charts is normalized to the values for the control pH (7.4). Error bars represent mean ± S.E.M. from at least three different samples. A two-tailed Student’s t-test was conducted on Figure 3A–3C with p-values * p<0.05, **p<0.01, *** p<0.001.