Table 2.
Summary of the subject demographics, results of the pulmonary function tests, and the ventilation defect percentage (VDP). All values are averages of measurements over two time points, and are reported as mean ± standard deviation for the cohort.
| YH (n=5) | YA (n=9) | OH (n=5) | OA (n=10) | |
|---|---|---|---|---|
| Subject Demographics | ||||
| Age years (± SD) | 23.2 (± 1.3) | 25.9 (± 6.4) | 63.4 (± 5.8) | 63.2 (± 6.1) |
| Male/Female | 2/3 | 2/7 | 2/3 | 3/7 |
| BMI (kg/m2) | 23.7 (± 2.5) | 29.0 (± 8.2) | 29.0 (± 5.2) | 30.3 (± 4.1) |
| ACQ | N/A | 1.3 (± 0.9) | N/A | 1.7 (± 1.2) |
| AQLQ | N/A | 6.1 (± 0.8) | N/A | 5.0 (± 1.9) |
| PFTs | ||||
| FEV1% | 106 (± 14.5) | 84 (± 16.1) | 95.8 (± 14.3) | 81.1 (± 19.8) |
| FVC% | 111.4 (± 12.8) | 98.8 (± 16.2) | 104.0 (± 18.1) | 96.4 (± 12.7) |
| FEV1/FVC | 81.0 (± 8.2) | 72.2 (± 7.1) | 71.7 (± 11.2) | 64.5 (± 11.2) |
| FEF25-75% | 96.2 (± 32.3) | 59.2 (± 21.9) | 87.3 (± 35.5) | 53.1 (± 26.9) |
| RV/TLC | 0.18 (± 0.02) | 0.29 (± 0.12) | 0.31 (± 0.05) | 0.40 (±0.05) |
| DLCO mmol CO | 86.8 (± 10.5) | 97.1 (± 10.8) | 89.5 (± 10.8) | 98.4 (± 17.3) |
| FeNO ppb | 16.8 (± 8.1) | 33.8 (± 21.4) | 15.6(± 10.2) | 36.9 (± 48.2) |
| Eos Sputum % | 4.0 (± 5.0) | 5.1 (± 7.2) | 9.3 (± 3.4) | 5.5 (± 3.8) |
| HP 129Xe MRI | ||||
| VDP | 5.6 (± 1.8) | 8.7 (± 3.2) | 11.6 (± 6.6) | 16.8 (± 10.3) |
YH=young healthy; YA=young asthmatic; OH=old healthy; OA=old asthmatic; ACQ=Asthma Control Questionnaire; AQLQ=Asthma Quality of Life Questionnaire; BMI=body mass index; FEV1%=forced expiratory volume in 1 second; FVC%=forced vital capacity; FEF=forced mid-expiratory flow rate; FeNO=fractional exhaled nitric oxide; RV/TLC=residual volume/total lung capacity; VDP=ventilation defect percentage