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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Virology. 2017 Apr 24;507:179–191. doi: 10.1016/j.virol.2017.04.021

Figure 9.

Figure 9

a. Under undifferentiated (monolayer) conditions, Pol II and CDK9 are present at the late promoter and initiate transcription, but elongating complexes do not continue to the end of the early region. b. Under differentiating conditions, the viral DNA loops to bring the LCR enhancer elements into association with the late promoter. Transcription factors binding to the enhancer and/or promoter recruit Brd4 or another BET family member, which then recruits CDK8. Either together or individually, CDK8 facilitates the processivity of elongating Pol II/CDK9 complexes to achieve complete transcription of the early region.