Figure 6.

Disruption of existing P. gingivalis/S. gordonii biofilms by BAR peptide and BAR-modified NPs. Two-species biofilms were formed and were subsequently incubated for 1 h with PBS or with PBS containing either free BAR peptide (3.0 µM) or BAR-modified NPs that delivered a final concentration of peptide of 0.3, 1.7, or 3.0 µM. Under these conditions, free peptide did not disrupt the dual-species biofilm. In contrast, a dose-dependent reduction of biofilm was observed with increasing peptide concentration delivered by BAR-modified NPs.

Abbreviations: NPs, nanoparticles; PBS, phosphate-buffered saline; P. gingivalis, Porphyromonas gingivalis; S. gordonii, Streptococcus gordonii.