Figure 3.

(A) Mitomycin plasma levels in isolated thoracic perfusion with chemofiltration versus intravenous application. Adapted with permission from Springer Nature book. Toxicity profiles with systemic versus regional chemotherapy. Induction Chemotherapy – Systemic and Locoregional, 2016, 497–506, Aigner KR, Knapp N;⁷ (B) cisplatin plasma levels in the thoracic aorta (dotted line) and in the vena cava (baseline) after intra-arterial pulsatile infusion of 80 mg cisplatin, demonstrating the so-called first-pass effect in intra-arterial chemotherapy. Adapted with permission from Springer Nature book. Toxicity profiles with systemic versus regional chemotherapy. Induction Chemotherapy – Systemic and Locoregional, 2016, 497–506, Aigner KR, Knapp N.⁷