Table 5.

Relationship between UGT1A1*6/*28 genotype and the incidence of adverse reactions associated with different tumors

Tumor	Genotyping	Leukopenia, n (%)		Neutropenia, n (%)		Nausea and vomiting, n (%)		Diarrhea, n (%)
		Grades I–II	Grades III–IV	Grades I–II	Grades III–IV	Grades I–II	Grades III–IV	Grades I–II	Grades III–IV
Lung cancer	G/G (n=35)	7 (20.00)	6 (17.14)	4 (11.43)	4 (11.43)	6 (17.14)	4 (11.43)	10 (28.57)	2 (5.71)
	G/A A/A (n=10)	3 (30.00)	0 (0)	0 (0)	0 (0)	4 (40.00)	0 (0)	2 (20.00)	0 (0)
P-value		0.811	0.379	0.561	0.561	0.270	0.561	0.893	1.000
Colorectal cancer	G/G (n=20)	7 (35.00)	1 (5.00)	5 (25.00)	6 (30.00)	15 (75.00)	0 (0)	5 (25.00)	1 (5.00)
	G/A A/A (n=7)	1 (14.29)	0 (0)	0 (0)	1 (14.29)	4 (57.14)	0 (0)	1 (14.29)	3 (42.86)
P-value		0.633	1.000	0.283	0.633	0.633	NG	1.000	0.042
Lung cancer	TA6/6 (n=34)	7 (20.59)	5 (14.71)	2 (5.88)	3 (8.82)	8 (23.53)	3 (8.82)	8 (23.53)	2 (5.88)
	TA6/7 TA7/7 (n=11)	3 (27.27)	1 (9.09)	2 (18.18)	1 (9.09)	2 (18.18)	1 (9.09)	4 (36.36)	0 (0)
P-value		0.963	1.000	0.247	1.000	1.000	1.000	0.657	1.000
Colorectal cancer	TA6/6 (n=20)	6 (30.00)	1 (5.00)	4 (20.00)	5 (25.00)	14 (70.00)	0 (0)	5 (25.00)	2 (10.00)
	TA6/7 TA7/7 (n=7)	2 (28.57)	0 (0)	1 (14.28)	2 (28.57)	5 (71.43)	0 (0)	1 (14.29)	2 (28.57)
P-value		1.000	1.000	1.000	1.000	1.000	NG	1.000	0.269
Lung cancer	Wild-type (n=24)	4 (16.67)	5 (20.83)	2 (8.33)	3 (12.50)	3 (12.50)	3 (12.50)	6 (25.00)	2 (8.33)
	Mutant type (n=21)	6 (28.57)	1 (4.76)	2 (9.52)	1 (4.76)	6 (28.57)	1 (4.76)	6 (28.57)	0 (0)
P-value		0.549	0.253	1.000	0.700	0.331	0.700	1.000	0.491
Colorectal cancer	Wild-type (n=15)	5 (33.33)	1 (6.67)	4 (26.67)	4 (26.67)	11 (73.33)	0 (0)	4 (26.67)	0 (0)
	Mutant type (n=12)	3 (25.00)	0 (0)	1 (8.33)	3 (25.00)	8 (66.67)	0 (0)	2 (16.67)	4 (33.33)
P-value		0.696	1.000	0.342	1.000	1.000	NG	0.662	0.028

Abbreviation: NG, not given.