Table 6.

Relationship between UGT1A1 genotype and the incidence of adverse reactions in patients of different ages

Age	Genotyping	Leukopenia, n (%)		Neutropenia, n (%)		Nausea and vomiting, n (%)		Diarrhea, n (%)
		Grades I–II	Grades III–IV	Grades I–II	Grades III–IV	Grades I–II	Grades III–IV	Grades I–II	Grades III–IV
<60	G/G (n=36)	13 (36.11)	5 (13.89)	6 (16.67)	7 (19.44)	16 (44.44)	0 (0)	10 (27.78)	0 (0)
	G/A A/A (n=12)	3 (27.27)	1 (9.09)	0 (0)	2 (18.18)	3 (27.27)	0 (0)	0 (0)	3 (25.00)
P-value		0.724	1.000	0.313	1.000	0.394	NG	0.101	0.013
≥60	G/G (n=26)	6 (23.08)	2 (7.69)	8 (30.77)	4 (15.38)	10 (38.46)	4 (15.38)	7 (26.92)	3 (11.54)
	G/A A/A (n=7)	2 (33.33)	0 (0)	0 (0)	1 (16.67)	6 (85.71)	0 (0)	1 (14.28)	0 (0)
P-value		1.000	1.000	0.154	1.000	0.039	0.555	0.652	1.000
<60	TA6/6 (n=34)	11 (32.35)	5 (14.71)	6 (17.65)	6 (17.65)	11 (32.35)	0 (0)	7 (20.59)	2 (5.88)
	TA6/7 TA7/7 (n=14)	3 (27.27)	1 (9.09)	1 (9.09)	3 (21.43)	6 (42.86)	0 (0)	4 (28.57)	1 (7.14)
P-value		0.684	0.810	0.626	1.000	0.719	NG	0.826	1.000
≥60	TA6/6 (n=27)	7 (25.93)	2 (7.41)	4 (14.81)	5 (18.52)	16 (59.26)	3 (11.11)	8 (29.63)	2 (7.41)
	TA6/7 TA7/7 (n=6)	3 (50.00)	0 (0)	3 (50.00)	0 (0)	2 (40.00)	1 (20.00)	1 (16.67)	1 (16.67)
P-value		0.336	1.000	0.093	0.556	0.375	1.000	1.000	0.464
<60	Wild-type (n=24)	7 (29.17)	4 (16.67)	5 (20.83)	4 (16.67)	9 (37.50)	0 (0)	6 (25.00)	0 (0)
	Mutant type (n=24)	6 (33.33)	2 (11.11)	1 (5.56)	5 (20.83)	9 (37.50)	0 (0)	5 (20.83)	3 (12.50)
P-value		0.754	0.663	0.190	1.000	1.000	NG	1.000	0.233
≥60	Wild-type (n=20)	6 (30.00)	2 (10.00)	5 (25.00)	4 (20.00)	10 (50.00)	3 (15.00)	7 (35.00)	2 (10.00)
	Mutant type (n=13)	5 (38.46)	0 (0)	3 (23.08)	1 (9.09)	7 (53.85)	1 (9.09)	3 (23.07)	1 (7.69)
P-value		0.714	0.508	1.000	0.625	1.000	1.000	0.701	1.000

Abbreviation: NG, not given.