Table 7.

Relationship between UGT1A1 genotypes and tumor response

Tumor	Genotyping	PR, n (%)	P-value	SD, n (%)	P-value	PD, n (%)	P-value
Lung cancer	G/G (n=21)	3 (14.28)	0.320	13 (61.90)	0.443	5 (23.81)	1.000
	G/A A/A (n=9)	3 (33.33)		4 (44.44)		2 (22.22)
	TA6/6 (n=23)	5 (21.74)	1.000	13 (56.52)	1.000	5 (21.74)	1.000
	TA6/7 TA7/7 (n=7)	1 (14.29)		4 (57.14)		2 (28.57)
	Wild-type (n=14)	2 (14.29)	0.657	9 (64.29)	0.484	3 (21.43)	1.000
	Mutant type (n=16)	4 (25.00)		8 (50.00)		4 (25.00)
Colorectal cancer	G/G (n=14)	4 (28.57)	0.530	8 (57.14)	0.603	2 (14.28)	1.000
	G/A A/A (n=5)	0 (0)		4 (80.00)		1 (20.00)
	TA6/6 (n=15)	2 (13.33)	0.178	10 (66.67)	0.603	3 (20.00)	1.000
	TA6/7 TA7/7 (n=4)	2 (50.00)		2 (50.00)		0 (0)
	Wild-type (n=11)	2 (18.18)	1.000	7 (63.64)	1.000	2 (18.18)	1.000
	Mutant type (n=8)	2 (25.00)		5 (62.50)		1 (12.50)

Abbreviations: PR, partial response; SD, stable disease; PD, progressive disease.