This figure shows age variation of R01 grantees. The median age grows from 40 to 50, whereas that of the 5% youngest grows from 32 to 37. The average age of first-(FIR) R01 grantees (ref. 15, black dotted line) is 6 y more than that of the 5% youngest, and halfway to the median age. Age changes for youngest, oldest, and median basic clinical-science PIs are shown in Fig. S1. Since 1980, US life expectancy has increased by 5 y (64).