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. 2017 Jun 5;114(25):E4924–E4933. doi: 10.1073/pnas.1615730114

Fig. 3.

Fig. 3.

Altered distribution of STAT3 and proteostasis in response to OPB-51602. (A) Proliferation of immortalized normal (LHS) and Ras-transformed (LHS-Ras) prostate epithelial cells treated with OPB-51602 with or without 2-DG. *P < 0.01. (B) STAT3 and pSTAT3 in H358 cells treated with OPB-51602 in CM or glucose-supplemented CM. (C) STAT3 reporter activity in stably engineered cell lines treated with OPB-51602 for 16 h in complete or glucose-depleted FM (GDM). *P < 0.01. (D) STAT3 and pSTAT3 in cytoplasm, nuclei, and whole-cell lysates from LNCaP treated with OPB-51602 for 16 h. (E) Distribution of STAT3, p62, ubiquitinated proteins, and HDAC6 in cell fractions from H358 cells untreated or treated with OPB-51602 for 16 h.