Fig. 5.

Protein–protein interaction network of Dox-induced differentially expressed synaptic vesicle and cholinergic genes. (A) Protein–protein interaction-based interconnected network of stringently defined 134 differentially expressed node genes and overall 427 genes. (B) Fold changes ± SEM of the synaptic vesicle cycle pathway genes within the network. (C) Fold changes ± SEM of the cholinergic synapse genes within the network. (D and E) Enriched biological process GO terms for PPI networks for genes differentially expressed following Dox, either down or up. (Fold enrichment, asterisks denote significance P value based on permutation analysis. Results were considered significant at *P < 0.05, **P < 0.01, ***P < 0.001, after correction for multiple testing when applicable.)