Skip to main content
. 2017 Jun 5;114(25):E4996–E5005. doi: 10.1073/pnas.1701201114

Fig. 6.

Fig. 6.

Mmu-miR-211–expressing mice show reduced memory abilities in the Morris water maze, and hsa-miR-211 is overexpressed in Alzheimer’s disease patient brains. (A) PANTHER classification of GO shows Dox-induced enrichment of differentially expressed gene groups, mainly regulation (Reg.) of neuron-related pathways in the dTg-211 brain transcripts (Methods). (B) Time to reach platform in the Morris water maze shows reduced learning ability in the first and second training days for dTg-211 mice. (C) Search strategy scores divided by trials and days for individual dTg-211 and CamK mice. Fewer trials of dTg-211 mice in the last days showed focal or directed strategy. (D) Loss of preference of the platform quadrant, reflecting impaired reference memory for dTg-211 compared with CamK mice in probe trials. (E) Higher miR-211 levels (∼twofold) in postmortem Alzheimer’s entorhinal cortices (73) compared with nondemented controls, n = 7 each, P < 0.05, Student’s t test. Results were considered significant at *P < 0.05, **P < 0.01, ***P < 0.001, after correction for multiple testing when applicable. ns, not significant.