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. 2017 Apr 7;4(2):141–152. doi: 10.1080/23328940.2017.1315478

Figure 1.

Figure 1.

Positions of amino acids involved in the responses of TRPV1 or TRPA1 to chemical and thermal stimuli. (A) Structures of a tetrameric (inset) or a single subunit of rat TRPV1 are shown with critical amino acids involved in its responses to capsaicin (cyan) and heat (magenta or green).9 Magenta and green arrows indicate amino acids that are involved in the responses of TRPV1 to heat in Xenopus and squirrels/camels, respectively.7,8 (B) Structures of a tetrameric (inset) or a single subunit of human TRPA1 are shown with critical amino acids involved in activation or inhibition by A-967079, HC-030031, and methyl anthranilate highlighted in cyan, magenta, and green, respectively.11,52,63,69,70,72 Critical amino acids involved in TRPA1 sensitivity to MA were identified using chicken TRPA1.52 TM, transmembrane domain; PH, pore helix; ARD, ankyrin repeat domain. TRP domain in TRPV1 and TRP-like domain in TRPA1 are enclosed by a magenta line. All figures were prepared using UCSF chimera.84 PBD ID for rat TRPV1 and human TRPA1 are 3J5R and 3J9P, respectively.