Table 4. Multivariable Cox Model with Time-Dependent Variable Adjusting for Age (N = 27)*.
| Hazard Ratio | 95% Confident Interval | P | ||
|---|---|---|---|---|
| VEGF | OS | 1.11 | .94-1.26 | .17 |
| PFS | 1.78 | 1.13-2.76 | .01 | |
| NRM | 1.04 | .21-4.07 | .96 | |
| Relapse | 1.95 | 1.21-3.13 | .007 | |
| cGVHD | 1.73 | .72-4.04 | .22 | |
| ANG-1 | OS | 1.01 | .86-1.15 | .95 |
| PFS | .98 | .84-1.11 | .74 | |
| NRM | .76 | .44-1.07 | .20 | |
| Relapse | 1.05 | .89-1.21 | .52 | |
| cGVHD | .96 | .68-1.20 | .78 | |
| TM | OS | 1.57 | 1.15-2.18 | .007 |
| PFS | 1.02 | .78-1.30 | .86 | |
| NRM | 1.97 | 1.22-3.9 | .02 | |
| Relapse | .80 | .54-1.11 | .21 | |
| cGVHD | 1.41 | 1.01-1.93 | .043 | |
| ANG-2 | OS | 1.07 | .97-1.15 | .10 |
| PFS | 1.04 | .99-1.09 | .14 | |
| NRM | 1.06 | .97-1.13 | .15 | |
| Relapse | 1.01 | .96-1.07 | .62 | |
| cGVHD | 1.01 | .80-1.08 | .90 |
*
Because of a small numbers of events, Cox univariable analysis was performed for NRM and cGVHD. Hazard ratio is per 100 pg/mL for VEGF and ANG-2 and per 1000 pg/mL for ANG-1 and TM.