Fig 2. Areas with multiple altered DTI indexes in bipolar disorder.

White matter tracts areas where fractional anisotropy, mean diffusivity, volume ratio, axial diffusivity and radial diffusivity show all a significant change in respect to healthy individual (in red, p = 0.05, corrected with threshold-free cluster enhancement) in patients with bipolar disorder. It can be noted that clusters of voxels, located in particular in the corpus callosum, in the external capsule and internal capsule show abnormalities in all the considered diffusion indexes. The white matter skeleton is depicted in blue.