Table 1. Variations of haemodynamic and renal parameters over time in phase II.
| Parameter | Time | T0 (Basal value) | T1 (% change) | T2 (% change) | T3 (% change) | T4 (% change) | T5 (% change) | T6 (% change) |
|---|---|---|---|---|---|---|---|---|
| CO (mL/min) | Group C | 104.7±22.5 | -2.8±5.3 | -5.3±3.6 | -9.4±5.0* | -10.3±3.7* | -12.9±4.4* | -12.5±7.2* |
| Group K | 106.1±20.8 | -4.5±4.4 | +0.1±2.6 | -4.7±3.2 | -6.2±3.8* | -5.3±5.9 | -1.4±8.4 | |
| Group KiNO | 109.5±24.7 | -0.7±2.6 | -4.7±3.1 | -7.8±3.1* | -8.9±3.3* | -3.6±4.5 | -2.2±4.8 | |
| mSAP (mmHg) | Group C | 82.6±9.71 | +4.8±3.1 | +9.6±7.5 | +15.6±8.2* | +14.8±8.1* | +16.1±9.1* | +15.8±9.2* |
| Group K | 71.3±13.3 | +9.1±5.7 | +12.2±7.8 | +18.2±8.9* | +17.1±9.3* | +15.3±9.7* | +15.8±8.8* | |
| Group KiNO | 86.6±6.1 | +7.7±3.7 | +14.4±6.5 | +14.8±7.3* | +16.5±7.6* | +15.7±8.7* | +14.7±9.8 | |
| RBFUL (mL/min) | Group C | 6.7±2.0 | -0.7±3.2 | -6.5±5.9 | -6.7±6.9 | -5.8±5.6 | -5.6±4.8 | -3.5±5.8 |
| Group K | 5.3±0.8 | -17.5±4.1* | -19.0±7.1* | -16.9±7.8* | -17.1±8.1* | -18.11±9.6* | -14.7±7.1* | |
| Group KiNO | 5.2±1.5 | -7.2±4.9 | -8.2±5.3 | -6.4±4.9 | -6.9±5.4 | -5.6±5.8 | -3.5±4.6 | |
| GFR (mL/min) | Group | 1.9±0.6 | -5.1 | -2.6 | -2.8 | +0.6 | +9.7 | +5.1 |
| C | ±11.5 | ±8.6 | ±9.9 | ±13.1 | ±19.6 | ±14.8 | ||
| Group K | 1.7±0.5 | -19.5±9.1* | -26.6±10.4* | -25.3±7.1* | -21.1±9.8* | -20.9±8.9* | -19.3±11.2 | |
| Group KiNO | 1.5±0.8 | -11.1±12.7 | +0.0±13.4 | -1.9±16.1 | -7.1±17.9 | -3.5±18.6 | -2.8±17.7 | |
| UO (μL/min) | Group C | 24.2±11.5 | +0.9±5.5 | +1.9±11.3 | -0.2±13.2 | +7.3±12.4 | +17.4±13.9 | +8.9±16.1 |
| Group K | 20.9±4.1 | -24.2±7.8* | -26.8±8.4* | -30.3±10.5* | -26.9±9.6* | -25.1±9.4* | -22.1±7.1* | |
| Group KiNO | 23.4±8.5 | -6.7±8.1 | -10.8±12.1 | +3.7±12.2 | +3.5±13.1 | -1.8±14.0 | -2.7±10.7 |
At the end of the baseline period (T0), piglets were randomly allocated to receive an IV injection of sterile placebo-control and inhaled 100% O2 (n = 6; Group C), an IV injection of ketoprofen and inhaled 100% O2 (n = 6; Group K), or IV ketoprofen and 40 ppm inhaled NO (n = 6; Group KiNO). Cardiac output (CO), mean systemic arterial blood pressure (mSAP), renal blood flow monitored with an ultrasonic probe (RBFUL), glomerular filtration rate (GFR) and urinary output (UO) of anaesthetised pigs were followed-up for seven successive 20-min periods (T0 to T6), with treatments administered at T1. Data are presented as mean percentage of change (±SD) from T1 to T6, compared with the mean value recorded in period T0.
* indicates a significant difference within time-points for the same parameter compared to baseline evaluated with a fixed-model for repeated measures.