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. 2017 Jun 28;12(6):e0179517. doi: 10.1371/journal.pone.0179517

Fig 4. Zebrafish possesses an ortholog of human TNFAIP8L3.

Fig 4

(A) Red dots represent regions of orthology between zebrafish and human chromosomal segments. Zebrafish (Danio rerio) chromosome 18 (Dre18) (gray dots), which contains the tnfaip8l3 gene, shares orthology with Hsa15, which contains the human TNFAIP8L3 gene. (B) Red dots represent regions of orthology between Hsa15 (gray dots) and the zebrafish genome. Evidence of two co-orthologous regions in zebrafish, likely arising from the TGD, are present in the region on Dre18 and Dre25. The tnfaip8l3 gene is present on Dre18. Additional co-orthologons are present on Dre17 and Dre20 and Dre7 and Dre25. The presence of the tnfaip8l3 orthologon on Dre18 is likely caused by a translocation event that occurred with Dre7. (C) Composite cluster mapping showing conserved synteny between Hsa15 and Dre18 in the regions surrounding human TNFAIP8L3 (red letters) and zebrafish tnfaip8l3 (red letters).