Fig 1. The relative timing and cortical volume impacts of CRH on dendritic growth in the fetus.

A) The relative timing of placental CRH expression, blood brain barrier development, cortical CRH expression, and cortical neurogenesis, migration and dendritic outgrowth in human gestation [25,32–34]. B) Relative human and rat cortical neuronal development. The relative timing of the cell culture experiment and treatment with CRH is indicated by the grey and orange boxes, respectively. C) Contribution of different cell types and structures to cortical volume. Based on data from Braitenberg & Schüz (1998).