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. 2017 Jun 28;12(6):e0180481. doi: 10.1371/journal.pone.0180481

Fig 4. A20 restricts interleukin (IL)-23 signal to IL-17 producing cells.

Fig 4

(A) Thickness of IL-23- or BSA-treated ears in A20+/- and A20+/+ littermate mice. Data are representative of two experiments. Error bars represent SEM; N = 3 (male, BSA injected group) or 9 (1 male and 8 female of A20+/- mice, and 2 male and 7 female of A20+/+ mice for IL-23-injected group) for each group,*p < 0.05 compared to IL-23-treated A20+/+ mice by Student’s t-test. (B) Numbers of TCRγδ+, TCRαβ+, IL-17+ TCRγδ+, and IL-17+ TCRαβ+ T cells from ear-draining lymph nodes from IL-23-treated or BSA-treated mice of indicated genotypes. Data are representative of two experiments. Error bars represent SEM; N = 3 (male, BSA-injected group) or 9 (1 male and 8 female of A20+/- mice, and 2 male and 7 female of A20+/+ mice for IL-23-injected group) for each group, *p < 0.05 compared to IL-23-treated A20+/+ mice by Student’s t-test.