Figure 3.

The profiles representing the tissue CA concentration (thin line) and the reconstructed profile after fitting and model selection (bold line) from (a) the normal tissue and (b) the tumor area as described in Figure 2. (c) and (d) show intra-vascular and extra-vascular components of the reconstructed tissue concentration profiles, based on the decomposition done by the Extended Vascular Model. As seen here, in the case where the signal sampled from the normal tissue (c), the extra-vascular component is a flat line, indicating no leakage to the extra-vascular space. But when the signal in sampled from the tumor (d) the intra-vascular and extra-vascular components are separated which can indicate the flow or extravasation properties of the vessels in the sampled region independently. The Sum of Squared Errors (SSE) for the fitted curves in (a) and (b) are 4.86 E-8 and 2.98 E-7 respectively.