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. Author manuscript; available in PMC: 2017 Sep 15.

Published in final edited form as: Int J Cancer. 2016 May 18;139(6):1231–1240. doi: 10.1002/ijc.30170

Induction-consolidation was scheduled at six weekly intervals of intravenous (A) cyclophosphamide (1200mg/m²) and (B) vincristine (1.5mg/m²); 4 weekly interval doses of intrathecal (C) methotrexate (7.5mg/m²); and (D) doxorubicin (60mg/m²) on days 1 and 22. Chemotherapy dosage status was defined by determining recommended doses based on retrospectively re-calculated BSA and comparing to dose of drugs received. Children who inadvertently received >115% of the recommended dose for a chemotherapy drug based on their re-calculated BSA were classified as overdosed, while children who received <85% of the recommended dose were classified as underdosed. Children who received doses within 15% of that recommended for their BSA were classified as correctly dosed.

Induction-consolidation was scheduled at six weekly intervals of intravenous (A) cyclophosphamide (1200mg/m²) and (B) vincristine (1.5mg/m²); 4 weekly interval doses of intrathecal (C) methotrexate (7.5mg/m²); and (D) doxorubicin (60mg/m²) on days 1 and 22. Chemotherapy dosage status was defined by determining recommended doses based on retrospectively re-calculated BSA and comparing to dose of drugs received. Children who inadvertently received >115% of the recommended dose for a chemotherapy drug based on their re-calculated BSA were classified as overdosed, while children who received <85% of the recommended dose were classified as underdosed. Children who received doses within 15% of that recommended for their BSA were classified as correctly dosed.

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