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. Author manuscript; available in PMC: 2017 Sep 15.
Published in final edited form as: Int J Cancer. 2016 May 18;139(6):1231–1240. doi: 10.1002/ijc.30170

Figure 4. Cumulative survival of children with endemic Burkitt lymphoma according to chemotherapy drug dosage status.

Figure 4

(A) Children who were inadvertently overdosed with cyclophosphamide were at increased risk of death compared to children who received correct dosing of cyclophosphamide (aHR=1.43, [0.84 to 2.43]). (D) Children overdosed with doxorubicin were at a slight increased risk of death or relapse (aHR: 1.25, [0.66 to 2.35]). In contrast, children underdosed with either of these two drugs, cyclophosphamide or doxorubicin, had similar survival rates as compared to children receiving correct doses of the respective agent. There were no appreciable differences in eBL survival by dosage status for (B) vincristine or (C) methotrexate. LR tests for the assumption of proportional hazards yielded overall p values varying between 0.121 and 0.247.

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