Figure 6.
The injectable nanoparticle generator (iNPG). a) Schematic representation of the iNPG. Polymeric doxorubicin (pDox) is loaded inside the pores of the silicon particle. Exposure to an aqueous environment, such as tumor vasculature, triggers the generation and release of polymeric doxorubicin nanoparticles that can enter the tissue interstitium through fenestrations in the vascular wall. b) Bioluminescence images of metastatic breast cancer tumors in the lungs of control mice and mice treated with the empty iNPG, Doxil, Dox, pDox nanoparticles (NP), and iNPG-pDox. c) Survival of mice. d) Diagram showing the biological barriers that Dox, pDox, and iNPG-pDOX are able to overcome. Reproduced from 73 with permission.