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. Author manuscript; available in PMC: 2017 Jun 28.
Published in final edited form as: Free Radic Biol Med. 2012 Apr 19;53(1):109–121. doi: 10.1016/j.freeradbiomed.2012.03.023

Fig. 4.

Fig. 4

8-OHdG inhibits monocyte/macrophage infiltration in ApoE KO mice and adhesion molecule expression in cultured VSMCs. (A) Histological analysis of monocyte/macrophage infiltration was obtained by MOMA-2 staining in LCAs. Consecutive sections are shown to compare Oil Red O stained areas with MOMA-2 stained areas. Scale bar; 100 μm. Also, enlarged images of MOMA-2 staining are shown. (B) Real-time PCR results of ICAM-1, VCAM-1, and MCP-1 in VSMCs after 24 h PDGF-BB (10 ng/mL) treatment. 8-OHdG (100 μg/mL) was pretreated for 1 h before PDGF-BB treatment. Values are means±SE of 4 experiments. *P<0.05 vs. control, †P<0.05 vs. PDGF-BB treated cells. ICAM-1; Inter-cellular adhesion molecule 1, VCAM-1; vascular cell adhesion molecule, MCP-1; monocyte chemotactic protein-1.