Fig. 1.

Body, liver and small intestine weights in Lal^+/+ and Lal^−/− mice given ezetimibe in their diet from 21 to 50 days of age. All mice were females fed a basal chow diet either alone or containing ezetimibe at a level of 0.0125% w/w which corresponded to an approximate dose of 20 mg/ day/ kg bw. These mice were then used mainly for the measurement of either the rate of cholesterol synthesis in the liver, small intestine and whole body, or for other parameters including the concentration of esterified and unesterified cholesterol in the liver and small intestine. Values are the mean ± SEM of data from 10 untreated mice of each genotype, and 11 of each genotype given ezetimibe. Different letters (a-c) denote statistically significant (p<0.05) differences as determined by 2-way ANOVA with genotype and treatment as variables.