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. Author manuscript; available in PMC: 2018 Jun 15.
Published in final edited form as: Cancer Res. 2017 May 8;77(12):3181–3193. doi: 10.1158/0008-5472.CAN-16-2797

Figure 1. Gene expression profiling of TWIST1 structure-function mutants revealed HOXA9 as a downstream target.

Figure 1

(A) Schematic of TWIST1 structure, T125D and S127D site-specific mutant, TWIST1-DQD, TWIST1-F191G. (B) Unsupervised hierarchal clustering heatmap visualization of gene expression differentially regulated by vector, TWIST1, TWIST1-DQD, and TWIST1-F191G. (C) Venn diagram represents significantly differentially expressed genes between Myc-CaP-TWIST1 and TWIST1 mutants. (D) GSEA analysis revealed that HOXA9 gene signatures were correlated with an increased EMT and metastatic phenotype.