Skip to main content
. Author manuscript; available in PMC: 2017 Jun 28.
Published in final edited form as: Immunol Rev. 2009 Jan;227(1):75–86. doi: 10.1111/j.1600-065X.2008.00737.x

Figure 1.

Figure 1

Differential roles of RIG-I and MDA5 in RNA virus recognition.

RIG-I recognizes 5′-triphosphate RNA and short dsRNA, whereas MDA5 discriminates long dsRNA generated during the course of virus infection. RNA viruses are differentially recognized by RIG-I and MDA5. RIG-I is responsible for detecting Paramyxoviridae, Orthomyxoviridae, Rhabdoviridae and some Flaviviridae family members. On the other hand, MDA5 recognizes Picornaviridae family members. Some viruses such as West Nile virus and Reovirus are detected by both RIG-I and MDA5. LGP2 is reported to be a genitive regulator for the RIG-I and MDA5 signaling.